Herbal Extract

Hawthorn Leaf Extract

Main ingredients: hawthorn flavonoids, vitexin rhamnoside, hypericin, etc.
Specifications: 1.8% Vitexin-2-O-Rhamnoside
Appearance: brownish yellow fine powder
Test method: HPLC
INQUIRY

Pharmacological effects:
1. Effects on the heart and cerebrovascular system Hawthorn flavonoids can be administrated in one or more doses to counteract the acute myocardium of rabbits induced by posterior pituitary Ischemia, narrow the scope of myocardial infarction. Hawthorn leaf extract (0.1g / ml) 0.4- 8ml / kg intravenous injection can significantly reduce or restore the ST segment uplift and T wave increase in guinea pig ECG caused by pituitary, and accelerate the Heart rate slows down. Vitexin rhamnose 20ml / kg can significantly reduce the myocardial oxygen consumption of the dog's in-situ heart, and has synergistic effect with hyperin. Gavage of water extracts of hawthorn leaves in rats can significantly reduce serum phosphocreatine kinase (CPK) levels and myocardial infarction area in coronary artery ligated rats. Injecting 20% hawthorn extract into the jugular vein for 5-7min, the cerebral vascular resistance decreased by 1.064-10.91kp / a (8-82mmHg).

2. Effects on the coagulation system Hawthorn leaves can significantly inhibit rabbit platelet aggregation induced by

collagen or ADP in vivo and in vitro. In addition, 30minutes after intravenous injection of hawthorn leaf preparation, the whole blood Specific viscosity decreased significantly.

3. Blood lipid-lowering effect Hawthorn leaves have a very significant effect on lowering cholesterolemia in mice with rapid formation of egg yolk emulsion.

4. Hypoxia-resistant effect Hawthorn leaves, like propranolol, can significantly prolong the survival time of hypobaric hypoxia or normal-pressure hypoxia experimental mice, which is consistent with the effect of significantly

reducing the overall oxygen consumption of mice.
5. Diuretic effect Hawthorn leaf extract has obvious diuretic effect. After 60 minutes of administration, the urine volume of rabbits increased by 44.2%, 53.9% at 90 minutes, and 63.7% at 120 minutes. Moreover, hawthorn leaves have little effect on electrolytes during diuresis.

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